Coumarins as modulators of the Keap1/Nrf2/ARE signaling pathway

EHM Hassanein, AM Sayed… - Oxidative Medicine …, 2020 - Wiley Online Library
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

The antithrombotic activity of natural and synthetic coumarins

L Gao, F Wang, Y Chen, F Li, B Han, D Liu - Fitoterapia, 2021 - Elsevier
Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …

Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects

TM Ramsis, MA Ebrahim, EA Fayed - Medicinal Chemistry Research, 2023 - Springer
Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …

From preclinical stroke models to humans: Polyphenols in the prevention and treatment of stroke

E Parrella, C Gussago, V Porrini, M Benarese, M Pizzi - Nutrients, 2020 - mdpi.com
Polyphenols are an important family of molecules of vegetal origin present in many
medicinal and edible plants, which represent important alimentary sources in the human …

Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

YG Razuvaeva, AA Toropova, SM Salchak… - Applied Sciences, 2023 - mdpi.com
Ferulopsis hystrix is a perennial plant of the Apiaceae family. In Buryat and Mongolian
medicine, it is used as a substitute for Costus speciosus roots (ru rta), and in Tibetan …

A song of ice and fire: cold and hot properties of traditional Chinese medicines

J Liu, W Feng, C Peng - Frontiers in Pharmacology, 2021 - frontiersin.org
The theory of cold and hot properties is the basic theory of traditional Chinese medicines
(TCMs) and has been successfully applied to combat human diseases for thousands of …

A review of antiplatelet activity of traditional medicinal herbs on integrative medicine studies

K Kim, KI Park - Evidence‐Based Complementary and …, 2019 - Wiley Online Library
Thrombotic events mainly occurred by platelet activation and aggregation. The vascular
occlusion causes serious disease states such as unstable angina, ischemic stroke, and …

Medicinal plants with antithrombotic property in Persian medicine: a mechanistic review

Z Memariani, R Moeini, SS Hamedi, N Gorji… - Journal of thrombosis …, 2018 - Springer
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels
diseases. Due to the high prevalence of thromboembolic disorders investigations are being …

Coumarin derivatives as anticancer agents for lung cancer therapy: A review

M Kumar, R Singla, J Dandriyal… - Anti-Cancer Agents in …, 2018 - ingentaconnect.com
Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer
cases worldwide. Currently, the number of drugs that are in clinical practice is having a high …

Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach

DA Fernandes, ANP Gomes, CM da Silva… - Current Medicinal …, 2024 - benthamdirect.com
Background: Thrombosis is one of the major causes of morbidity and mortality in a wide
range of vessel diseases. Several studies have been conducted to identify antithrombotic …