Sex matters: a comprehensive comparison of female and male hearts

SR St. Pierre, M Peirlinck, E Kuhl - Frontiers in physiology, 2022 - frontiersin.org
Cardiovascular disease in women remains under-diagnosed and under-treated. Recent
studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic …

A framework for developing sex-specific engineered heart models

R Lock, H Al Asafen, S Fleischer, M Tamargo… - Nature Reviews …, 2022 - nature.com
The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

Clinical Phenotypes and Prognosis of Dilated Cardiomyopathy Caused by Truncating Variants in the TTN Gene

MM Akhtar, M Lorenzini, M Cicerchia… - Circulation: Heart …, 2020 - Am Heart Assoc
Background: Truncating variants in the TTN gene (TTNtv) are the commonest cause of
heritable dilated cardiomyopathy. This study aimed to study the phenotypes and outcomes …

Contemporary survival trends and aetiological characterization in non‐ischaemic dilated cardiomyopathy

M Merlo, A Cannatà, C Pio Loco… - European Journal of …, 2020 - Wiley Online Library
Aim Contemporary survival trends in dilated cardiomyopathy (DCM) are largely unknown.
The aim of this study is to investigate clinical descriptors, survival trends and the prognostic …

New insights in RBM20 cardiomyopathy

D Lennermann, J Backs… - Current heart failure …, 2020 - Springer
Abstract Purpose of Review This review aims to give an update on recent findings related to
the cardiac splicing factor RNA-binding motif protein 20 (RBM20) and RBM20 …

Sex differences in heart: from basics to clinics

C Prajapati, J Koivumäki, M Pekkanen-Mattila… - European Journal of …, 2022 - Springer
Sex differences exist in the structure and function of human heart. The patterns of ventricular
repolarization in normal electrocardiograms (ECG) differ in men and women: men ECG …

Risk of sports-related sudden cardiac death in women

D Rajan, R Garcia, J Svane… - European heart …, 2022 - academic.oup.com
Sudden cardiac death (SCD) is a tragic incident accountable for up to 50% of deaths from
cardiovascular disease. Sports-related SCD (SrSCD) is a phenomenon which has …

Sex matters: the frequently overlooked importance of considering sex in computational models

KS Burrowes, M Ruppage, A Lowry, D Zhao - Frontiers in Physiology, 2023 - frontiersin.org
Personalised medicine and the development of a virtual human or a digital twin comprises
visions of the future of medicine. To realise these innovations, an understanding of the …

Mortality risk in dilated cardiomyopathy: the accuracy of heart failure prognostic models and dilated cardiomyopathy‐tailored prognostic model

E Dziewięcka, M Gliniak, M Winiarczyk… - ESC heart …, 2020 - Wiley Online Library
Aims The aims of this paper were to investigate the analytical performance of the nine
prognostic scales commonly used in heart failure (HF), in patients with dilated …

Machine learning and bioinformatics framework integration to potential familial DCM-related markers discovery

C Schiano, M Franzese, F Geraci, M Zanfardino… - Genes, 2021 - mdpi.com
Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome.
Since the DCM molecular network is largely unknown, the aim was to identify specific …