Primary hyperoxaluria (PH) is an inherited disorder that results from the overproduction of
endogenous oxalate, leading to recurrent kidney stones, nephrocalcinosis and eventually …

Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic
overproduction of oxalate that leads to kidney stones, nephrocalcinosis, kidney failure, and …

Primary hyperoxaluria (PH) is a rare autosomal recessive disease characterized by oxalate
accumulation in the kidneys and other organs. Three loci have been identified: AGXT (PH1) …

The prevalence of kidney stones is increasing in industrialized nations, resulting in a
corresponding rise in economic burden. Nephrolithiasis is now recognized as both a chronic …

Systemic diseases of liver origin (SDLO) are complex diseases in multiple organ systems,
such as cardiovascular, musculoskeletal, endocrine, renal, respiratory, and sensory organ …

Accurate diagnosis of primary hyperoxaluria (PH) has important therapeutic consequences.
Since biochemical assessment can be unreliable, genetic testing is a crucial diagnostic tool …

Primary hyperoxalurias are a devastating family of diseases leading to multisystem oxalate
deposition, nephrolithiasis, nephrocalcinosis and end-stage renal disease. Traditional …

Hyperoxaluria is a frequent complication of inflammatory bowel diseases, ileal resection and
Roux-en-Y gastric bypass and is well-known to cause nephrolithiasis and nephrocalcinosis …

Primary hyperoxaluria (PH) patients overproduce oxalate because of rare genetic errors in
glyoxylate metabolism. Recurrent urolithiasis and/or progressive nephrocalcinosis are PH …