Epigenetic factors are critical regulators of biological and pathological mechanisms and they
could interact with different molecular pathways. Targeting epigenetic factors has been an …

The acquisition of cancer cell resistance to conventional chemotherapeutics is considered
the major driver of treatment failure and disease recurrence in most solid and hematological …

Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …

Background Ovarian cancer (OC) is one of the leading causes of cancer related deaths
among women. Due to the asymptomatic tumor progression and lack of efficient screening …

Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …

Gynecological cancers are the second most common types of cancer in women. Clinical
diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their …

Ovarian cancer (OC) is the leading cause of death from gynecological malignancies.
Despite great advances in treatment strategies, therapeutic resistance and the gap between …

It is now definitively established that a large part of the human genome is transcribed.
However, only a scarce percentage of the transcriptome (about 1.2%) consists of RNAs that …

Emerging data have indicated that long non‑coding RNAs (lncRNA) are associated with the
pathogenesis of endometriosis. However, few are associated with endometriosis‑associated …

Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has
broadened the repertoire of preclinical models and progressively revolutionized three …