Tumor progression involves invasion, migration, metabolism, autophagy, exosome
secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

A large group of small Rab GTPases which mediate secretory and endosomal membrane
transport, as well as autophagosome biogenesis, are essential components of vesicle …

All cells in the changing tumor microenvironment (TME) need a class of checkpoints to
regulate the balance among exocytosis, endocytosis, recycling and degradation. The …

Background: Increased IL-6 level, M2 macrophages and PD-1+ CD8+ T cells in tumor
microenvironments (TME) have been identified to correlate with resistance to checkpoint …

Rationale: The role of SLUG in epithelial-mesenchymal transition during tumor progression
has been thoroughly studied, but its precise regulation remains poorly explored. Methods …

Exosomes are small extracellular vesicles that originate from the intraluminal vesicles of
multivesicular bodies (MVBs). We previously reported that polarized Madin-Darby canine …

Background: Chitinase 3-like-1 (CHI3L1) is a secretion glycoprotein associated with the
immunosuppressive tumor microenvironment (TME). The secretory mode of CHI3L1 makes …

The Rab GTPase family of proteins are mediators of membrane trafficking, conferring identity
to the cell membranes. Recently, Rab and Rab-associated factors have been recognized as …

Rab GTPases are major mediators that ensure the proper spatiotemporal regulation of
intracellular trafficking. Functional impairment and altered expression of Rab proteins have …