The sensory epithelia of the inner ear contain mechanosensory hair cells and non-sensory
supporting cells. Both classes of cell are heterogeneous, with phenotypes varying both …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

The homeobox Six genes, homologues to Drosophila sine oculis (so) gene, are expressed
in multiple organs during mammalian development. However, their roles during auditory …

The inner ear is partitioned along its dorsal/ventral axis into vestibular and auditory organs,
respectively. Gene expression studies suggest that this subdivision occurs within the otic …

Abstract Recent years have seen a renaissance of investigation into the mechanisms of
inner ear development. Genetic analysis of zebrafish has contributed significantly to this …

Patterning the vertebrate ear requires the coordinated expression of genes that are involved
in morphogenesis, neurogenesis, and hair cell formation. The zinc finger gene GATA‐3 is …

Generating the diversity of cell types in the inner ear may require an interplay between
regional compartmentalization and local cellular interactions. Recent evidence has come …

We have investigated the expression of FGF10 during ear development and the effect of an
FGF10 null mutation on ear development. Our in situ hybridization data reveal expression of …

The otocyst harbors progenitors for most cell types of the mature inner ear. Developmental
lineage analyses and gene expression studies suggest that distinct progenitor populations …

The highly orchestrated processes that generate the vertebrate inner ear from the otic
placode provide an excellent and circumscribed testing ground for fundamental cellular and …