[HTML][HTML] Small but perfectly formed? Successes, challenges, and opportunities for microfluidics in the chemical and biological sciences
Microfluidic systems are pervasive in many areas of experimental science, but what are the
real advantages of this technology? We describe some of the features and properties that …
real advantages of this technology? We describe some of the features and properties that …
[HTML][HTML] The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6
is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal …
is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal …
Axon–soma communication in neuronal injury
I Rishal, M Fainzilber - Nature Reviews Neuroscience, 2014 - nature.com
The extensive lengths of neuronal processes necessitate efficient mechanisms for
communication with the cell body. Neuronal regeneration after nerve injury requires new …
communication with the cell body. Neuronal regeneration after nerve injury requires new …
[HTML][HTML] Long-Term Imaging of Caenorhabditis elegans Using Nanoparticle-Mediated Immobilization
E Kim, L Sun, CV Gabel, C Fang-Yen - PloS one, 2013 - journals.plos.org
One advantage of the nematode Caenorhabditis elegans as a model organism is its
suitability for in vivo optical microscopy. Imaging C. elegans often requires animals to be …
suitability for in vivo optical microscopy. Imaging C. elegans often requires animals to be …
[HTML][HTML] Caspases in the developing central nervous system: Apoptosis and beyond
TTM Nguyen, G Gillet, N Popgeorgiev - Frontiers in Cell and …, 2021 - frontiersin.org
The caspase family of cysteine proteases represents the executioners of programmed cell
death (PCD) type I or apoptosis. For years, caspases have been known for their critical roles …
death (PCD) type I or apoptosis. For years, caspases have been known for their critical roles …
[HTML][HTML] Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging
W Yuan, YM Weaver, S Earnest, CA Taylor IV… - Nature …, 2023 - nature.com
The conserved p38 MAPK family is activated by phosphorylation during stress responses
and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune …
and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune …
[HTML][HTML] Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration
The microtubule (MT) cytoskeleton of a mature axon is maintained in a stabilized steady
state, yet after axonal injury it can be transformed into a dynamic structure capable of …
state, yet after axonal injury it can be transformed into a dynamic structure capable of …
[HTML][HTML] Mitochondrial ROS and the effectors of the intrinsic apoptotic pathway in aging cells: the discerning killers!
S Hekimi, Y Wang, A Noë - Frontiers in Genetics, 2016 - frontiersin.org
It has become clear that mitochondrial reactive oxygen species (mtROS) are not simply
villains and mitochondria the hapless targets of their attacks. Rather, it appears that …
villains and mitochondria the hapless targets of their attacks. Rather, it appears that …
The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans
The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …
processes during development. In the past two decades, great progress has been made in …