Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by extensive
synovitis resulting in erosions of articular cartilage and marginal bone that lead to joint …

As soon as autoinflammatory diseases (AIDs) emerged as new entities, they have been
linked to the well known world of autoimmunity. In fact, AIDs and systemic autoimmune …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

This review focuses on the recent advancements in the understanding of innate immunity in
the pathogenesis of osteoarthritis, particularly with attention to the roles of damage …

Abstract Purpose of the Review Mounting evidence supports a role of low-grade
inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of …