Hierarchical biomechanics: concepts, bone as prominent example, and perspectives beyond

C Hellmich, N Ukaj, B Smeets… - Applied …, 2022 - asmedigitalcollection.asme.org
The main motivation for “hierarchical biomechanics” is that the wide variability of mechanical
properties encountered at the macroscopic scale may be traced back to just a few …

Patient-specific bone multiscale modelling, fracture simulation and risk analysis—a survey

ACS Alcântara, I Assis, D Prada, K Mehle, S Schwan… - Materials, 2019 - mdpi.com
This paper provides a starting point for researchers and practitioners from biology, medicine,
physics and engineering who can benefit from an up-to-date literature survey on patient …

[HTML][HTML] Experimentally informed micromechanical modelling of cement paste: An approach coupling X-ray computed tomography and statistical nanoindentation

H Zhang, B Šavija, M Luković, E Schlangen - Composites Part B …, 2019 - Elsevier
This work proposes a method for numerically investigating the fracture mechanism of
cement paste at the microscale based on X-ray computed tomography and nanoindentation …

Toward an artificial intelligence‐assisted framework for reconstructing the digital twin of vertebra and predicting its fracture response

H Ahmadian, P Mageswaran, BA Walter… - … journal for numerical …, 2022 - Wiley Online Library
This article presents an effort toward building an artificial intelligence (AI) assisted
framework, coined ReconGAN, for creating a realistic digital twin of the human vertebra and …

[HTML][HTML] Hierarchical elastoplasticity of cortical bone: observations, mathematical modeling, validation

V Kumbolder, C Morin, S Scheiner, C Hellmich - Mechanics of Materials, 2024 - Elsevier
Motivated by the water layer-coated nanoscale bone mineral crystals and the elastoplastic
behavior seen at the extracellular scale, we develop a six-step hierarchical micromechanics …

Anisotropic elastic properties of human femoral cortical bone and relationships with composition and microstructure in elderly

X Cai, H Follet, L Peralta, M Gardegaront, D Farlay… - Acta Biomaterialia, 2019 - Elsevier
The strong dependence between cortical bone elasticity at the millimetre-scale (mesoscale)
and cortical porosity has been evidenced by previous studies. However, bone is an …

Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling

Y Peng, X Du, L Huang, J Li, R Zhan, W Wang… - Medical & Biological …, 2018 - Springer
Vertebroplasty is a common and effective treatment for symptomatic osteoporotic vertebral
compression fractures. However, the cemented and adjacent vertebras have a risk of …

In Silico Clinical Trials in the Orthopedic Device Industry: From Fantasy to Reality?

P Favre, G Maquer, A Henderson, D Hertig… - Annals of Biomedical …, 2021 - Springer
The orthopedic device industry relies heavily on clinical evaluation to confirm the safety,
performance, and clinical benefits of its implants. Limited sample size often prevents these …

Multi-scale modelling predicts plant stem bending behaviour in response to wind to inform lodging resistance

T Gangwar, AQ Susko, S Baranova… - Royal Society …, 2023 - royalsocietypublishing.org
Lodging impedes the successful cultivation of cereal crops. Complex anatomy, morphology
and environmental interactions make identifying reliable and measurable traits for breeding …

3D patient-specific finite element models of the proximal femur based on DXA towards the classification of fracture and non-fracture cases

CR Wills, AL Olivares, S Tassani, M Ceresa, V Zimmer… - Bone, 2019 - Elsevier
Osteoporotic bone fractures reduce quality of life and drastically increase mortality.
Minimally irradiating imaging techniques such as dual-energy X-ray absorptiometry (DXA) …