Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of
organic pyrophosphates, including nucleoside di-and triphosphates, dinucleoside and …

Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other
moieties, X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The …

The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as
mRNA processing. Although highly conserved throughout all organisms, their biological …

Crystal structures of the extracellular ligand-binding region of the metabotropic glutamate
receptor, complexed with an antagonist,(S)-(α)-methyl-4-carboxyphenylglycine, and with …

Decapping of mRNA is a critical step in eukaryotic mRNA turnover, yet the proteins involved
in this activity remain elusive in mammals. We identified the human Dcp2 protein (hDcp2) as …

Jumbo phages have attracted much attention by virtue of their extraordinary genome size
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …

The targets of the Structural GenomiX (SGX) bacterial genomics project were proteins
conserved in multiple prokaryotic organisms with no obvious sequence homolog in the …

RNA decapping is an important contributor to gene expression and is a critical determinant
of mRNA decay. The recent demonstration that mammalian cells harbor at least two distinct …

A critical step in mRNA degradation is the removal of the 5′ cap structure, which is
catalyzed by the Dcp1-Dcp2 complex. The crystal structure of an S. pombe Dcp1p-Dcp2n …

Cancer cells maintain high levels of reactive oxygen species (ROS) to drive their growth, but
ROS can trigger cell death through oxidative stress and DNA damage. To survive enhanced …