Background DNA bridging promoted by the H-NS protein, combined with the compaction
induced by cellular crowding, plays a major role in the structuring of the E. coli genome …

We perform a single molecule force spectroscopy study to characterize the role of the size
(molecular weight) and concentration of depleting agents on DNA condensation and on the …

In biological systems, conformational transformations of nucleic acids play critical roles in
genetic regulation. However, it remains a tricky task to design and optimize specific labeling …

In this work, we have studied the interaction between the anticancer drug doxorubicin (doxo)
and condensed DNA, using optical tweezers. To perform this task, we use the protein bovine …

DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and
Techniques provides the reader with all the main information, a" state-of-the-art" of sorts and …

Conformational transitions from secondary (eg, B-to A-form DNA) to higher-order (eg, coil to
globule) transitions play important roles in genome expression and maintenance. Several …

In the last few decades, the constant development of novel microscopy techniques have
created the basis for a new paradigm in the field of biophysics. Single-molecule techniques …