Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors
of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster …

Insects have evolved a chemical communication system using terpenoids, a structurally
diverse class of specialized metabolites, previously thought to be exclusively produced by …

The regioselective hydro/deuterophosphonylation of electron-rich alkenes with P (O) H
compounds has been realized via a metal-free electrochemically induced strategy …

Novel analogues of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs)
are described that are potent inhibitors of the human geranylgeranyl pyrophosphate …

Intramolecular hydroarylation-redox cross-dehydrogenative coupling of N-propargylanilines
with phosphite diesters proceeded in the presence of Cu (I)-catalysts (20 mol%) to …

The treatment of diethyl α, β‐dehydroaminophosphonate 1 with various arenes (ArH=
toluene 2 a, benzene 2 b, anisole 2 c, bromobenzene 2 d, chlorobenzene 2 e, benzyl …

Mevalonate kinase is a key regulator of the mevalonate pathway, subject to feedback
inhibition by the downstream metabolite farnesyl pyrophosphate. In this study, we validated …

An asymmetric Rh-catalyzed transfer hydrogenation was developed for the conversion of α-
enamidophosphonates to α-aminophosphonates (α-APs) using isopropanol as the hydride …

Surface plasmon resonance (SPR) biosensor methods are ideally suited for fragment-based
lead discovery. However, generally applicable experimental procedures and detailed …

The hydrogenation of N-substituted vinylphosphonates using rhodium complexes derived
from P–OP ligands L1, ent-L1, or (R, R)-Me-DuPHOS as catalysts has been successfully …