Accelerating research and development of new vaccines against tuberculosis: a global roadmap

F Cobelens, RK Suri, M Helinski… - The Lancet Infectious …, 2022 - thelancet.com
To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently
needed, particularly for use in adults and adolescents in low-income and middle-income …

Vaccine development against tuberculosis over the last 140 years: Failure as part of success

SHE Kaufmann - Frontiers in Microbiology, 2021 - frontiersin.org
The year 2020 was shaped by the COVID-19 pandemic which killed more people than any
other infectious disease in this particular year. At the same time, the development of highly …

Vaccination against tuberculosis: revamping BCG by molecular genetics guided by immunology

SHE Kaufmann - Frontiers in immunology, 2020 - frontiersin.org
Tuberculosis (TB) remains a major health threat. Although a vaccine has been available for
almost 100 years termed Bacille Calmette-Guérin (BCG), it is insufficient and better vaccines …

Update on TB vaccine pipeline

C Martin, N Aguilo, D Marinova, J Gonzalo-Asensio - Applied Sciences, 2020 - mdpi.com
In addition to antibiotics, vaccination is considered among the most efficacious methods in
the control and the potential eradication of infectious diseases. New safe and effective …

Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice

S Afkhami, MR D'Agostino, M Vaseghi-Shanjani… - npj Vaccines, 2023 - nature.com
Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of
inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately …

A mathematical study of a tuberculosis model with fractional derivatives

H Abboubakar, P Kumar, VS Erturk… - International Journal of …, 2021 - World Scientific
In this work, we use a Predictor–Corrector method to implement and derive an iterative
solution of an existing Tuberculosis (TB) model with two fractional derivatives, namely …

Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates

L Shen, J Frencher, D Huang… - Proceedings of the …, 2019 - National Acad Sciences
Tuberculosis (TB) remains a leading killer among infectious diseases, and a better TB
vaccine is urgently needed. The critical components and mechanisms of vaccine-induced …

[HTML][HTML] Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination

M Coppola, THM Ottenhoff - Seminars in immunology, 2018 - Elsevier
Every day approximately six thousand people die of Tuberculosis (TB). Its causative agent,
Mycobacterium tuberculosis (Mtb), is an ancient pathogen that through its evolution …

Insights and challenges in tuberculosis vaccine development

H McShane - The Lancet Respiratory Medicine, 2019 - thelancet.com
Tuberculosis kills more people than any other pathogen and the need for a universally
effective vaccine has never been greater. An effective vaccine will be a key tool in achieving …

Lipoarabinomannan in active and passive protection against tuberculosis

M Correia-Neves, C Sundling, A Cooper… - Frontiers in …, 2019 - frontiersin.org
Glycolipids of the cell wall of Mycobacterium tuberculosis (Mtb) are important
immunomodulators in tuberculosis. In particular, lipoarabinomannan (LAM) has a profound …