Due to the limit of available treatments and the emergence of drug resistance in the clinic,
invasive fungal infections are an intractable problem with high morbidity and mortality. The …

Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid
residue (2, 4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a …

Nature's repertoire of bio-halogenase enzymes is intriguing with halogenases from various
natural product biosynthetic clusters that carry out site and region-specific halogenation of …

Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public
health threat. The development of antimalarial drug resistance is reversing the gains made …

Resorcylic acid lactones (RALs) are naturally occurring 14-membered macrolactones that
constitute a class of polyketides derived from fungal metabolites and that possess significant …

Abstract Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum (ER) resident
isoform of the 90 kDa heat shock protein (Hsp90) family and its inhibition represents a …

Cancer is one of the leading causes of death globally, accounting for an estimated 8 million
deaths each year. As a result, there have been urgent unmet medical needs to discover …

Objective: To investigate 33 organic extracts of mangrove plants for: antiparasitic,
anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the α …

Abstract Heat shock protein 90 (HSP90) is a molecular chaperone that plays important
functional roles in cells. The chaperone activity of HSP90 is regulated by the hydrolysis of …

The natural products cochliomycin A (1) and cochliomycin B (2), two resorcylic acid lactones
obtained from marine sources, have been prepared in a concise and stereocontrolled …