Ewing sarcoma
Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …
The ETS family of oncogenic transcription factors in solid tumours
Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …
Review of various NAMPT inhibitors for the treatment of cancer
Y Wei, H Xiang, W Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the NAD
salvage pathway of mammalian cells and is overexpressed in numerous types of cancers …
salvage pathway of mammalian cells and is overexpressed in numerous types of cancers …
PARP inhibitors in cancer diagnosis and therapy
Targeting of PARP enzymes has emerged as an effective therapeutic strategy to selectively
target cancer cells with deficiencies in homologous recombination signaling. Currently used …
target cancer cells with deficiencies in homologous recombination signaling. Currently used …
EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma
AB Iniguez, B Stolte, EJ Wang, AS Conway, G Alexe… - Cancer cell, 2018 - cell.com
Many cancer types are driven by oncogenic transcription factors that have been difficult to
drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers …
drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers …
Unique features of trabectedin mechanism of action
AK Larsen, CM Galmarini, M D'Incalci - Cancer chemotherapy and …, 2016 - Springer
Abstract Trabectedin (Yondelis®, ET-743) is a marine-derived natural product that was
initially isolated from the marine ascidian Ecteinascidia turbinata and is currently prepared …
initially isolated from the marine ascidian Ecteinascidia turbinata and is currently prepared …
A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma
LM Guenther, NV Dharia, L Ross, A Conway… - Clinical Cancer …, 2019 - AACR
Purpose: Novel targeted therapeutics have transformed the care of subsets of patients with
cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent …
cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent …
Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations
Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic
regimes, which are largely unsuccessful in advanced patients. Preclinical models are …
regimes, which are largely unsuccessful in advanced patients. Preclinical models are …
[HTML][HTML] Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma
B Stolte, AB Iniguez, NV Dharia… - The Journal of …, 2018 - ncbi.nlm.nih.gov
Ewing sarcoma is a pediatric cancer driven by EWS-ETS transcription factor fusion
oncoproteins in an otherwise stable genomic background. The majority of tumors express …
oncoproteins in an otherwise stable genomic background. The majority of tumors express …
BRCA1/2 Functional Loss Defines a Targetable Subset in Leiomyosarcoma
ND Seligson, EA Kautto, EN Passen, C Stets… - The …, 2019 - academic.oup.com
Background Soft‐tissue sarcomas (STS) describe a heterogeneous group of mesenchymal
tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations …
tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations …