Animal experimentation helps us to understand human biology. Rodents and, in particular,
rats are among the most common animals used in animal experiments. Reporting data on …

With each trajectory taken during the ontogeny of an individual, the number of optional
behavioural phenotypes that can be expressed across its life span is reduced. The initial …

Addressing age-related immunological defects through therapeutic interventions is essential
for healthy aging, as the immune system plays a crucial role in controlling infections …

New 2-oxo-chromene-7-oxymethylene acetohydrazide derivatives 4a–d were designed and
synthesized with a variety of bioactive chemical fragments. The newly synthesized …

Among the hallmarks of aged organisms are an accumulation of misfolded proteins and a
reduction in skeletal muscle mass (" sarcopenia"). We have examined the effects of aging …

Lifelong dietary restriction (DR) is known to have many potential beneficial effects on brain
function as well as delaying the onset of neurological diseases. In the present investigation …

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

We here review the loss of muscle function and mass (sarcopenia) in the framework of
human healthspan and lifespan, and mechanisms involved in aging. The rapidly changing …

In recent years, the disappointing history of translation in pain research has undergone
significant scrutiny. The escalation of knowledge and understanding related to presumed …