Angstrom-scale ion channels towards single-ion selectivity

H Zhang, X Li, J Hou, L Jiang, H Wang - Chemical Society Reviews, 2022 - pubs.rsc.org
Artificial ion channels with ion permeability and selectivity comparable to their biological
counterparts are highly desired for efficient separation, biosensing, and energy conversion …

Anion transport and supramolecular medicinal chemistry

PA Gale, JT Davis, R Quesada - Chemical Society Reviews, 2017 - pubs.rsc.org
New approaches to the transmembrane transport of anions are discussed in this review.
Advances in the design of small molecule anion carriers are reviewed in addition to …

Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity

JC Liu, JF Wang, Q Han, P Shangguan… - Angewandte …, 2021 - Wiley Online Library
The hierarchical aggregation of molecular nanostructures from multiple components is a
grand synthetic challenge, which requires highly selective linkage control. We demonstrate …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

Self‐assembled artificial ion‐channels toward natural selection of functions

S Zheng, L Huang, Z Sun… - Angewandte Chemie …, 2021 - Wiley Online Library
Owing to their significant physiological functions, especially as selective relays for
translocation of physiological relevant species through cellular membranes, natural ion …

Metallacarborane cluster anions of the cobalt bisdicarbollide-type as chaotropic carriers for transmembrane and intracellular delivery of cationic peptides

Y Chen, A Barba-Bon, B Grüner… - Journal of the …, 2023 - ACS Publications
Cobalt bisdicarbollides (COSANs) are inorganic boron-based anions that have been
previously reported to permeate by themselves through lipid bilayer membranes, a …

An artificial molecular shuttle operates in lipid bilayers for ion transport

S Chen, Y Wang, T Nie, C Bao, C Wang… - Journal of the …, 2018 - ACS Publications
Inspired by natural biomolecular machines, synthetic molecular-level machines have been
proven to perform well-defined mechanical tasks and measurable work. To mimic the …

[PDF][PDF] Prospects and challenges in anion recognition and transport

X Wu, AM Gilchrist, PA Gale - Chem, 2020 - cell.com
The genesis of anion receptor chemistry can be traced back to the late 1960s with the work
of Shriver and Biallas on chelating Lewis acids and Park and Simmons on ammonium …

Supramolecular chemistry in lipid bilayer membranes

LE Bickerton, TG Johnson, A Kerckhoffs… - Chemical Science, 2021 - pubs.rsc.org
Lipid bilayer membranes form compartments requisite for life. Interfacing supramolecular
systems, including receptors, catalysts, signal transducers and ion transporters, enables the …

[PDF][PDF] Artificial transmembrane ion transporters as potential therapeutics

J Yang, G Yu, JL Sessler, I Shin, PA Gale, F Huang - Chem, 2021 - cell.com
Various artificial transmembrane transporters, designed to function through mobile carrier or
channel mechanisms, have been developed in the past decade. With the aid of structural …