The use of intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: evidence-based indications and safety profile
MC Dalakas - Pharmacology & therapeutics, 2004 - Elsevier
Intravenous immunoglobulin (IVIg) has multiple actions on the immunoregulatory network
that operate in concert with each other. For each autoimmune neuromuscular disease …
that operate in concert with each other. For each autoimmune neuromuscular disease …
Mechanisms of action of IVIg and therapeutic considerations in the treatment of acute and chronic demyelinating neuropathies
MC Dalakas - Neurology, 2002 - AAN Enterprises
Intravenous immunoglobulin (IVIg) is an immunomodulating agent that has multiple
activities, including modulation of complement activation products, suppressing idiotypic …
activities, including modulation of complement activation products, suppressing idiotypic …
Intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: present status and practical therapeutic guidelines
MC Dalakas - Muscle & Nerve: Official Journal of the American …, 1999 - Wiley Online Library
This review summarizes the current status of intravenous immunoglobulin (IVIg) in the
treatment of autoimmune neuromuscular disorders and the possible mechanisms of action …
treatment of autoimmune neuromuscular disorders and the possible mechanisms of action …
Impact of autoantibody glycosylation in autoimmune diseases
R Goulabchand, T Vincent, F Batteux, J Eliaou… - Autoimmunity …, 2014 - Elsevier
Objective: Recent outcomes enhanced the critical role of glycosylation pattern of
autoantibodies in the pathophysiology of antibody-mediated autoimmune diseases. In this …
autoantibodies in the pathophysiology of antibody-mediated autoimmune diseases. In this …
Sialylation levels of anti–proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)
Objective To investigate whether the glycosylation and sialylation levels of anti–proteinase 3
(anti‐PR3) antibodies could affect their pathogenicity, and whether these levels could be …
(anti‐PR3) antibodies could affect their pathogenicity, and whether these levels could be …
Immunoglobulins inhibit pathophysiological effects of anti‐GQ1b‐positive sera at motor nerve terminals through inhibition of antibody binding
BC Jacobs, GM O'Hanlon, RWM Bullens, J Veitch… - Brain, 2003 - academic.oup.com
High‐dose intravenous immunoglobulin (IVIg) is an effective treatment for many antibody‐
mediated neuromuscular diseases, suggesting that IVIg directly interferes with the pathways …
mediated neuromuscular diseases, suggesting that IVIg directly interferes with the pathways …
Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy—a new mechanism of action?
S Bick, M Tschernatsch, A Karg, V Fuehlhuber… - Journal of …, 2013 - Elsevier
Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated
disease treated with intravenous immunoglobulin (IVIg). The underlying mechanism of …
disease treated with intravenous immunoglobulin (IVIg). The underlying mechanism of …
The effect of container surface passivation on aggregation of intravenous immunoglobulin induced by mechanical shock
Aggregation of therapeutic proteins can result from a number of stress conditions
encountered during their manufacture, transportation, and storage. This work shows the …
encountered during their manufacture, transportation, and storage. This work shows the …
Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma
GN Kaufman, AH Massoud… - Clinical & …, 2011 - Wiley Online Library
Background Intravenous immunoglobulin (IVIG) has potent anti‐inflammatory and immune‐
modulating properties. IVIG has been utilized as a steroid‐sparing agent in severe asthma …
modulating properties. IVIG has been utilized as a steroid‐sparing agent in severe asthma …
Intravenous immunoglobulin treatment of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis
SH Jorgensen, PS Sorensen - Journal of the neurological sciences, 2005 - Elsevier
Intravenous immunoglobulin (IVIG) is an established treatment of immune-mediated
demyelinating neuropathy. Since IVIG possesses multiple immunomodulatory and anti …
demyelinating neuropathy. Since IVIG possesses multiple immunomodulatory and anti …