Cognitive impairment is a debilitating side effect experienced by patients with cancer treated
with systemically administered anticancer therapies. With around 19.3 million new cases of …

Immune checkpoint inhibitors have revolutionized immunotherapy against various cancers
over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of …

Summary Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

Abstract Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have
emerged as a treatment for multiple advanced cancer types. Because of enhanced immune …

Stroke is a severe and life-threatening disease, necessitating more research on new
treatment strategies. Infiltrated T lymphocytes, an essential adaptive immune cell with …

The approval of immune checkpoint inhibitors (ICIs) by the Food and Drug Administration
(FDA) led to an improvement in the treatment of several types of cancer. The main targets of …

The braking mechanisms to protect the host from tissue damage and inflammatory disease
caused by an overexuberant immune response are common in many T cell subsets …

The lack of effective and safe analgesics for chronic pain management has been a health
problem associated with people's livelihoods for many years. Analgesic peptides have …

Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative
disorder characterized by the loss of upper and lower motor neurons in the brain and spinal …