Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management
B Fleming, P Edison, L Kenny - bmj, 2023 - bmj.com
Cognitive impairment is a debilitating side effect experienced by patients with cancer treated
with systemically administered anticancer therapies. With around 19.3 million new cases of …
with systemically administered anticancer therapies. With around 19.3 million new cases of …
The role of immune checkpoint molecules on macrophages in cancer, infection, and autoimmune pathologies
VC Brom, C Burger, DC Wirtz… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoint inhibitors have revolutionized immunotherapy against various cancers
over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of …
over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of …
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
Summary Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …
Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury
L Gong, Y Gu, X Han, C Luan, C Liu, X Wang… - Neuroscience …, 2023 - Springer
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …
Mechanistic insights into immune checkpoint inhibitor-related hypophysitis: a form of paraneoplastic syndrome
K Kanie, G Iguchi, H Bando, S Urai, H Shichi… - Cancer Immunology …, 2021 - Springer
Abstract Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have
emerged as a treatment for multiple advanced cancer types. Because of enhanced immune …
emerged as a treatment for multiple advanced cancer types. Because of enhanced immune …
[HTML][HTML] T-cell receptor signaling modulated by the co-receptors: Potential targets for stroke treatment
Stroke is a severe and life-threatening disease, necessitating more research on new
treatment strategies. Infiltrated T lymphocytes, an essential adaptive immune cell with …
treatment strategies. Infiltrated T lymphocytes, an essential adaptive immune cell with …
[HTML][HTML] PD-1/PD-L axis in neuroinflammation: new insights
S Manenti, M Orrico, S Masciocchi, A Mandelli… - Frontiers in …, 2022 - frontiersin.org
The approval of immune checkpoint inhibitors (ICIs) by the Food and Drug Administration
(FDA) led to an improvement in the treatment of several types of cancer. The main targets of …
(FDA) led to an improvement in the treatment of several types of cancer. The main targets of …
IL-10 negatively controls the primary T cell response of tilapia by triggering the JAK1/STAT3/SOCS3 axis that suppresses NF-κB and MAPK/ERK signaling
K Li, J Li, X Wei, J Wang, M Geng, K Ai… - The Journal of …, 2023 - journals.aai.org
The braking mechanisms to protect the host from tissue damage and inflammatory disease
caused by an overexuberant immune response are common in many T cell subsets …
caused by an overexuberant immune response are common in many T cell subsets …
An analgesic peptide H-20 attenuates chronic pain via the PD-1 pathway with few adverse effects
L Zhao, H Luo, Y Ma, S Zhu, Y Wu… - Proceedings of the …, 2022 - National Acad Sciences
The lack of effective and safe analgesics for chronic pain management has been a health
problem associated with people's livelihoods for many years. Analgesic peptides have …
problem associated with people's livelihoods for many years. Analgesic peptides have …
CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
S Zaccai, A Nemirovsky, L Lerner, L Alfahel… - Journal of …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative
disorder characterized by the loss of upper and lower motor neurons in the brain and spinal …
disorder characterized by the loss of upper and lower motor neurons in the brain and spinal …