Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease
KI Eissa, MM Kamel, LW Mohamed… - Drug Development …, 2023 - Wiley Online Library
A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …
Development of new Alzheimer's disease drug candidates using donepezil as a key model
KI Eissa, MM Kamel, LW Mohamed… - Archiv der …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most prevalent geriatric diseases and a significant
cause of high mortality. This crippling disorder is becoming more prevalent at an …
cause of high mortality. This crippling disorder is becoming more prevalent at an …
Multidisciplinary approaches for advanced enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics
Enzyme biocatalysis is reshaping pharmaceutical synthesis, offering sustainable and
efficient pathways for drug discovery and production. This paradigm shift towards eco …
efficient pathways for drug discovery and production. This paradigm shift towards eco …
Sahlep (Dactylorhiza osmanica): Phytochemical Analyses by LC-HRMS, Molecular Docking, Antioxidant Activity, and Enzyme Inhibition Profiles
Studies have shown an inverse correlation among age-related illnesses like coronary heart
disease and cancer and intake of fruit and vegetable. Given the probable health benefits of …
disease and cancer and intake of fruit and vegetable. Given the probable health benefits of …
Comprehensive metabolic profiling of Acantholimon caryophyllaceum using LC–HRMS and evaluation of antioxidant activities, enzyme inhibition properties and …
The Acantholimon taxon consists of thorny, perennial and subshrub flowering plants.
Extraction of various Acantholimon species are traditionally applied to treat liver disease and …
Extraction of various Acantholimon species are traditionally applied to treat liver disease and …
In vitro inhibition of acetylcholinesterase activity by yellow field pea (Pisum sativum) protein-derived peptides as revealed by kinetics and molecular docking
Compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly
used to inhibit the activity of acetylcholinesterase (AChE) in Alzheimer's disease (AD) …
used to inhibit the activity of acetylcholinesterase (AChE) in Alzheimer's disease (AD) …
Enhanced Antioxidant and Neuroprotective Properties of Pterostilbene (Resveratrol Derivative) in Amorphous Solid Dispersions
N Rosiak, E Tykarska, J Cielecka-Piontek - International Journal of …, 2024 - mdpi.com
In this study, amorphous solid dispersions (ASDs) of pterostilbene (PTR) with
polyvinylpyrrolidone polymers (PVP K30 and VA64) were prepared through milling, affirming …
polyvinylpyrrolidone polymers (PVP K30 and VA64) were prepared through milling, affirming …
Biological activity and molecular docking studies of some N‐phenylsulfonamides against cholinesterases and carbonic anhydrase isoenzymes
In this research, a series of N‐phenylsulfonamide derivatives (1‐12) were designed,
synthesized, and investigated for their inhibitory potencies against carbonic anhydrase …
synthesized, and investigated for their inhibitory potencies against carbonic anhydrase …
Exploring Recent Updates on Molecular Docking: Types, Method, Application, Limitation & Future Prospects
MK Sahu, AK Nayak, B Hailemeskel… - International Journal of …, 2024 - ijpras.com
Molecular docking serves as a crucial computational tool in the realm of drug discovery and
development, aimed at understanding the interactions between small molecules and target …
development, aimed at understanding the interactions between small molecules and target …
New indole derivatives as multitarget anti-Alzheimer's agents: synthesis, biological evaluation and molecular dynamics
Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …