Alternative mechanisms of miR-34a regulation in cancer
MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …
DEAD-box RNA helicases and genome stability
M Cargill, R Venkataraman, S Lee - Genes, 2021 - mdpi.com
DEAD-box RNA helicases are important regulators of RNA metabolism and have been
implicated in the development of cancer. Interestingly, these helicases constitute a major …
implicated in the development of cancer. Interestingly, these helicases constitute a major …
[HTML][HTML] Systematic discovery of RNA binding proteins that regulate microRNA levels
JK Nussbacher, GW Yeo - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) interact with primary, precursor, and mature microRNAs
(miRs) to influence mature miR levels, which in turn affect critical aspects of human …
(miRs) to influence mature miR levels, which in turn affect critical aspects of human …
Regulation of primary micro RNA processing
A Creugny, A Fender, S Pfeffer - FEBS letters, 2018 - Wiley Online Library
Micro RNA s (mi RNA s) are evolutionarily conserved small regulatory RNA s that participate
in the adjustment of many, if not all, fundamental biological processes. Molecular …
in the adjustment of many, if not all, fundamental biological processes. Molecular …
A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression
Y He, D Zhang, Y Yang, X Wang… - Oncology …, 2018 - spandidos-publications.com
Abstract DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-
box proteins in all eukaryotes from yeasts to human beings. Accumulating studies have …
box proteins in all eukaryotes from yeasts to human beings. Accumulating studies have …
MicroRNA-34a: a versatile regulator of myriads of targets in different cancers
MicroRNA-34a (miR-34a) is a tumor suppressor that has attracted considerable attention in
recent years. It modulates cancer cell invasion, metastasis, and drug resistance, and has …
recent years. It modulates cancer cell invasion, metastasis, and drug resistance, and has …
DEAD-BOX RNA HELICASE 27 regulates microRNA biogenesis, zygote division, and stem cell homeostasis
XL Hou, WQ Chen, Y Hou, HQ Gong, J Sun… - The Plant …, 2021 - academic.oup.com
After double fertilization, zygotic embryogenesis initiates a new life cycle, and stem cell
homeostasis in the shoot apical meristem (SAM) and root apical meristem (RAM) allows …
homeostasis in the shoot apical meristem (SAM) and root apical meristem (RAM) allows …
PHGDH is upregulated at translational level and implicated in platin-resistant in ovarian cancer cells
F Bi, Y An, T Sun, Y You, Q Yang - Frontiers in Oncology, 2021 - frontiersin.org
Background Platinum-based chemotherapy is the first line option for ovarian cancer. The
development of resistance to such chemotherapy results in treatment failure, while the …
development of resistance to such chemotherapy results in treatment failure, while the …
PerturbSci-Kinetics: Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens
Abstract Here we described PerturbSci-Kinetics, a novel combinatorial indexing method for
capturing three-layer single-cell readout (ie, whole transcriptome, nascent transcriptome …
capturing three-layer single-cell readout (ie, whole transcriptome, nascent transcriptome …
[HTML][HTML] miR-19b promotes breast cancer metastasis through targeting MYLIP and its related cell adhesion molecules
L Zhao, Y Zhao, Y He, Y Mao - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract miR-19b is a key molecule for cancer development, however its crucial roles in
breast cancer metastasis are rarely studied right now. In this study, using several …
breast cancer metastasis are rarely studied right now. In this study, using several …