Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
components that generate adaptive and evolutionarily driven aberrant tissues in the central …
[HTML][HTML] Cancer stemness meets immunity: from mechanism to therapy
Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …
metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many …
Circadian regulator BMAL1:: CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
[HTML][HTML] The crosstalk between tumor-associated macrophages (TAMs) and tumor cells and the corresponding targeted therapy
Z Ge, S Ding - Frontiers in oncology, 2020 - frontiersin.org
Tumor microenvironment (TME) is composed of tumor cells and surrounding non-tumor
stromal cells, mainly including tumor associated macrophages (TAMs), endothelial cells …
stromal cells, mainly including tumor associated macrophages (TAMs), endothelial cells …
Brain‐targeted HFn‐Cu‐rego nanoplatform for site‐specific delivery and manipulation of autophagy and cuproptosis in glioblastoma
W Jia, H Tian, J Jiang, L Zhou, L Li, M Luo, N Ding… - Small, 2023 - Wiley Online Library
Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …
[HTML][HTML] Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects
X Wang, H Ding, Z Li, Y Peng, H Tan, C Wang… - … and Targeted Therapy, 2022 - nature.com
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an extremely low
survival rate. New and effective approaches for treatment are therefore urgently needed …
survival rate. New and effective approaches for treatment are therefore urgently needed …
[HTML][HTML] Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma
Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …
Circadian regulator CLOCK drives immunosuppression in glioblastoma
The symbiotic interactions between cancer stem cells and the tumor microenvironment
(TME) are critical for tumor progression. However, the molecular mechanism underlying this …
(TME) are critical for tumor progression. However, the molecular mechanism underlying this …