Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Gap junctions are plasma membrane spatial microdomains constructed of assemblies of
channel proteins called connexins in vertebrates and innexins in invertebrates. The …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells …

Evidence accumulated over the past two decades has indicated that exposure of cell
populations to ionizing radiation results in significant biological effects occurring in both the …

An essential feature of the first synapse in the retina is a negative feedback pathway from
horizontal cells to cones. Here we show that at this synapse, connexin26 forms …

Gap junctions have traditionally been characterized as nonspecific pores between cells
passing molecules up to 1kDa in molecular mass. Nonetheless, it has become increasingly …

Direct cell-to-cell communication through specialized intercellular channels is a
characteristic feature of virtually all multi-cellular organisms. The remarkable functional …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Gap junctions were initially described morphologically, and identified as semi-crystalline
arrays of channels linking two cells. This suggested that they may represent an amenable …