Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has
attracted an exponentially growing interest. A key driver for this trend was the ability to image …

Pexidartinib (PLX3397) is a small molecule receptor tyrosine kinase inhibitor of colony
stimulating factor 1 receptor (CSF1R) with moderate selectivity over other members of the …

Epilepsy, characterized by recurrent spontaneous seizures, is a heterogeneous group of
brain diseases affecting over 70 million people worldwide. Major challenges in the …

Introduction Astrocytes have previously been considered as cells supporting neuronal
functions, but they are now recognized as active players in maintaining central nervous …

There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy.
The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury …