Light is essential for various biochemical processes in all domains of life. In its presence
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …

Noncanonical amino acids (ncAAs) for photo‐and chemical crosslinking are powerful
biochemical tools for studying and manipulating interactions between proteins both in vitro …

Chromatin is a system of proteins and DNA that regulates chromosome organization and
gene expression in eukaryotes. Essential features that support these processes include …

Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate
gene functions. Most of these epigenetic marks are added or removed by corresponding …

Diazirines are versatile carbene precursors that are extensively used in biological target
identification experiments. However, their photo-activation wavelength (ca. 365 nm) …

Nucleosome remodeling provides access to genomic DNA for recruitment of the
transcriptional machinery to mediate gene expression. The aberrant function of nucleosome …

Methyllysine sites in proteins are recognized by an array of reader domains that mediate
protein–protein interactions for controlling cellular processes. Herein, we engineer a …

Bromodomain containing protein 1 (BRD1) plays critical roles in chromatin acetylation, gene
transcription, erythropoiesis, and brain development. BRD1 is also implicated in several …

In synthetic biology, the artificial control of proteins by light is of growing interest since it
enables the spatio-temporal regulation of downstream molecular processes. This precise …

Current experiments that rely on biosynthetic metabolic protein labeling with 19 F often
require fluorinated amino acids, which in the case of 2-and 3-fluorotyrosine can be …