[HTML][HTML] Chalcone: a promising bioactive scaffold in medicinal chemistry
G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
B Mathew, DGT Parambi, GE Mathew… - Archiv der …, 2019 - Wiley Online Library
No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
Halogenated coumarin–chalcones as multifunctional monoamine oxidase-B and butyrylcholinesterase inhibitors
A series of halogenated coumarin–chalcones were synthesized, characterized, and their
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …
Medicinal perspective of indole derivatives: recent developments and structure-activity relationship studies
Heterocyclic compounds play a significant role in various biological processes of the human
body and many of them are in clinical use due to their diverse, chemical and biological …
body and many of them are in clinical use due to their diverse, chemical and biological …
Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors
JM Oh, SC Baek, JP Lee, AR Tondo, O Nicolotti… - Bioorganic …, 2019 - Elsevier
The present study documents the synthesis of oxygenated chalcone (O1–O26) derivatives
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …
Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage
Oxidative stress represents a disorder of the redox equilibrium between the production of
free radicals and the capability of cells to eliminate them. As subversion of this redox …
free radicals and the capability of cells to eliminate them. As subversion of this redox …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
[HTML][HTML] Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
JM Oh, HJ Jang, MG Kang, S Song, DY Kim, JH Kim… - Scientific Reports, 2021 - nature.com
Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems
was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors …
was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors …