Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …

Atrial septal defects are the third most common type of congenital heart disease. Included in
this group of malformations are several types of atrial communications that allow shunting of …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

In the recent era, no congenital heart defect has undergone a more dramatic change in
diagnostic approach, management, and outcomes than hypoplastic left heart syndrome …

The intent of this review is to provide the clinician with a summary of what is currently known
about the contribution of genetics to the origin of congenital heart disease. Techniques are …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Congenital heart disease is a major cause of morbidity and mortality throughout life.
Mutations in numerous transcription factors have been identified in patients and families with …

During heart development the second heart field (SHF) provides progenitor cells for most
cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that …

Human mutations in Nkx2-5 lead to progressive cardiomyopathy and conduction defects via
unknown mechanisms. To define these pathways, we generated mice with a ventricular …

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network,
guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in …