Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

Exosomes in cardiovascular disease: from mechanism to therapeutic target

AB Reiss, S Ahmed, M Johnson, U Saeedullah… - Metabolites, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In
recent decades, clinical research has made significant advances, resulting in improved …

Extracellular vesicles: the future of diagnosis in solid organ transplantation?

N Romero-García, J Huete-Acevedo… - International Journal of …, 2023 - mdpi.com
Solid organ transplantation (SOT) is a life-saving treatment for end-stage organ failure, but it
comes with several challenges, the most important of which is the existing gap between the …

Basic pathogenic mechanisms and epigenetic players promoted by extracellular vesicles in vascular damage

C Schiano, C Balbi, F de Nigris, C Napoli - International Journal of …, 2023 - mdpi.com
Both progression from the early pathogenic events to clinically manifest cardiovascular
diseases (CVD) and cancer impact the integrity of the vascular system. Pathological …

Role of miR‐15a‐5p and miR‐199a‐3p in the inflammatory pathway regulated by NF‐κB in experimental and human atherosclerosis

P González‐López, M Álvarez‐Villarreal… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Cardiovascular diseases (CVDs) prevalence has significantly
increased in the last decade and atherosclerosis development is the main trigger …

Vascular calcification: from the perspective of crosstalk

S Yang, Z Zeng, Q Yuan, Q Chen, Z Wang, H Xie… - Molecular …, 2023 - Springer
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and
mortality, but anti-VC treatment remains an area to be tackled due to the ill-defined …

[HTML][HTML] Extracellular vesicles in atherosclerosis and vascular calcification: The versatile non-coding RNAs from endothelial cells and vascular smooth muscle cells

F Yu, Y Duan, C Liu, H Huang, X Xiao, Z He - Frontiers in Medicine, 2023 - ncbi.nlm.nih.gov
Atherosclerosis (AS) is characterized by the accumulation of lipids, fibrous elements, and
calcification in the innermost layers of arteries. Vascular calcification (VC), the deposition of …

[HTML][HTML] circRNA, a novel diagnostic biomarker for coronary heart disease

X Tong, X Zhao, X Dang, Y Kou, J Kou - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Objective: This study aimed to identify the potential diagnostic biomarkers of coronary heart
disease (CHD) from exosome-derived circRNA. Methods: The microarray data of circRNA …

Extracellular Vesicles in the Skin Microenvironment: Emerging Roles as Biomarkers and Therapeutic Tools in Dermatologic Health and Disease

JP Flemming, PJ Wermuth, MG Mahoney - Journal of Investigative …, 2023 - Elsevier
The recent discovery of extracellular vesicles (EVs) carrying cargo consisting of various
bioactive macromolecules that can modulate the phenotype of recipient target cells has …

Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques

F Brandes, AS Meidert, B Kirchner, M Yu… - Frontiers in …, 2024 - frontiersin.org
Background Atherosclerosis is a widespread disorder of the cardiovascular system. The
early detection of plaques by circulating biomarkers is highly clinically relevant to prevent …