Modulating the neuromodulators: dopamine, serotonin, and the endocannabinoid system

KZ Peters, JF Cheer, R Tonini - Trends in neurosciences, 2021 - cell.com
Dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and endocannabinoids (ECs) are
key neuromodulators involved in many aspects of motivated behavior, including reward …

Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications

P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Serotonergic neurons signal reward and punishment on multiple timescales

JY Cohen, MW Amoroso, N Uchida - Elife, 2015 - elifesciences.org
Serotonin's function in the brain is unclear. One challenge in testing the numerous
hypotheses about serotonin's function has been observing the activity of identified …

The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking

JM Monti, H Jantos - Progress in brain research, 2008 - Elsevier
Based on electrophysiological, neurochemical and neuropharmacological approaches, it is
currently accepted that serotonin (5-HT) and dopamine (DA) function to promote waking (W) …

Meta-learning in reinforcement learning

N Schweighofer, K Doya - Neural Networks, 2003 - Elsevier
Meta-parameters in reinforcement learning should be tuned to the environmental dynamics
and the animal performance. Here, we propose a biologically plausible meta-reinforcement …

Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions

BP Guiard, M El Mansari, Z Merali… - International Journal of …, 2008 - academic.oup.com
Anatomical studies have established the existence of reciprocal relationships between the
main population of monoamine, serotonin (5-HT), norepinephrine (NE) and dopamine (DA) …

Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei

A Adell, P Celada, MT Abellán, F Artigas - Brain Research Reviews, 2002 - Elsevier
There is considerable interest in the regulation of the extracellular compartment of the
transmitter serotonin (5-hydroxytryptamine, 5-HT) in the midbrain raphe nuclei because it …

Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems

S Manta, M El Mansari, G Debonnel… - International Journal of …, 2013 - academic.oup.com
Vagus nerve stimulation (VNS) is an adjunctive treatment for resistant epilepsy and
depression. Electrophysiological recordings in the rat brain have already shown that chronic …

Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus

K Nakamura, M Matsumoto… - Journal of Neuroscience, 2008 - Soc Neuroscience
The dopamine system has been thought to play a central role in guiding behavior based on
rewards. Recent pharmacological studies suggest that another monoamine …

Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil

WM Qu, ZL Huang, XH Xu, N Matsumoto… - Journal of …, 2008 - Soc Neuroscience
Modafinil is a wake-promoting compound with low abuse potential used in the treatment of
narcolepsy. Although the compound is reported to affect multiple neurotransmitter systems …