In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

In mammals, dosage compensation between XX and XY individuals occurs through X
chromosome inactivation (XCI). The noncoding Xist RNA is expressed and initiates XCI only …

Estrogen-related receptors (ERRα, β and γ in mammals) are orphan members of the nuclear
receptor superfamily acting as transcription factors. ERRs are expressed in several cell …

Gene expression specificity of homeobox transcription factors has remained paradoxical.
WUSCHEL activates and represses CLAVATA3 transcription at lower and higher …

Engineered signaling networks can impart cells with new functionalities useful for directing
differentiation and actuating cellular therapies. For such applications, the engineered …

Transcriptional activity of the hypoxia inducible factor (HIF) relies on the formation of a
heterodimer composed of an oxygen-regulated α-subunit and a stably expressed β-subunit …

With the advent of nanotechnology, concepts related to the Internet of Things, such as the
Internet of NanoThings and Internet of Bio-NanoThings (IoBNT) have also emerged in the …

Genes in prokaryotic and eukaryotic cells are typically regulated by complex promoters
containing multiple binding sites for a variety of transcription factors leading to a specific …

Based on the measurements of noise in gene expression performed during the past decade,
it has become customary to think of gene regulation in terms of a two-state model, where the …

Pregnancy-induced changes in drug pharmacokinetics can be explained by changes in
expression of drug-metabolizing enzymes and transporters and/or normal physiology. In this …