Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …

Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

Background The objective of this study was to determine whether neurotoxic kynurenine
metabolites, induced by inflammation, in plasma and cerebrospinal fluid (CSF) are …

Neurodegenerative disorders are typically sporadic in nature in addition to usually
influenced through an extensive range of environmental factors, lifestyle, and genetic …

Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …

Characterisation and diagnosis of idiopathic Parkinson's disease (iPD) is a current
challenge that hampers both clinical assessment and clinical trial development with the …

Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …

Both preclinical and clinical studies implicate functional impairments of several neuroactive
metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential …

Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly
involved in energy metabolism and DNA production. Alterations in tryptophan metabolism …