The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

Differential gene expression is the fundamental mechanism underlying animal development
and cell differentiation. However, it is a challenge to identify comprehensively and accurately …

Combinatorial transcription factor (TF) interactions control cellular phenotypes and,
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …

Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …

T cell development comprises a stepwise process of commitment from a multipotent
precursor. To define molecular mechanisms controlling this progression, we probed five …

Previous reports of GATA2 mutations have focused on the coding region of the gene or full
gene deletions. We recently identified 2 patients with novel insertion/deletion mutations …

Advancing pluripotent stem cell technologies for modelling haematopoietic stem cell
development and blood therapies requires identifying key regulators of haematopoietic …

The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is
critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in …

Conservation of the vertebrate body plan has been attributed to the evolutionary stability of
gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1 …

EGFL7 is a secreted angiogenic factor that is highly conserved in vertebrates. Most secreted
angiogenic signaling molecules, including VEGF and fibroblast growth factor-2, are mainly …