Biocatalytic phosphorylations of metabolites: past, present, and future

R Wohlgemuth, A Liese, W Streit - Trends in biotechnology, 2017 - cell.com
Phosphorus is a key element for life that occurs in living cells as a structural part of many key
biochemicals. Phosphorus plays important functional roles in biocatalysis, such as making …

The power of biocatalysts for highly selective and efficient phosphorylation reactions

R Wohlgemuth - Catalysts, 2022 - mdpi.com
Reactions involving the transfer of phosphorus-containing groups are of key importance for
maintaining life, from biological cells, tissues and organs to plants, animals, humans …

Local Electric Field Modulated Reactivity of Pseudomonas aeruginosa Acid Phosphatase for Enhancing Phosphorylation of l-Ascorbic Acid

X Xu, S Yan, X Hou, W Song, L Wang, T Wu, M Qi… - ACS …, 2021 - ACS Publications
Acid phosphatases (APases) are attractive enzymes for catalyzing large-scale industrial
phosphorylation reactions owing to their capacity of utilizing cheap phosphate donors as …

Route selection and reaction engineering for sustainable metabolite synthesis

R Wohlgemuth - Reaction Chemistry & Engineering, 2023 - pubs.rsc.org
The great advances in information technology, machine learning and artificial intelligence
are providing fast access to potential routes to a desired metabolite from possible starting …

Key advances in biocatalytic phosphorylations in the last two decades: Biocatalytic syntheses in vitro and biotransformations in vivo (in humans)

R Wohlgemuth - Biotechnology Journal, 2021 - Wiley Online Library
Biocatalytic phosphorylation reactions provide several benefits, such as more direct, milder,
more selective, and shorter access routes to phosphorylated products. Favorable …

Synthesis of metabolites and metabolite-like compounds using biocatalytic systems

R Wohlgemuth - Metabolites, 2023 - mdpi.com
Methodologies for the synthesis and purification of metabolites, which have been developed
following their discovery, analysis, and structural identification, have been involved in …

Horizons of systems biocatalysis and renaissance of metabolite synthesis

R Wohlgemuth - biotechnology Journal, 2018 - Wiley Online Library
The small molecule domain of biological cellular systems is closely related to the synthesis
and breakdown of larger molecules such as DNA, RNA, proteins, or polysaccharides …

Biocatalytic process design and reaction engineering

R Wohlgemuth - Chemical and Biochemical Engineering Quarterly, 2017 - hrcak.srce.hr
Sažetak Biocatalytic processes occurring in nature provide a wealth of inspiration for
manufacturing processes with high molecular economy. The molecular and engineering …

Facile synthesis of D-xylulose-5-phosphate and L-xylulose-5-phosphate by xylulokinase-catalyzed phosphorylation

N Hardt, S Kind, B Schoenenberger… - Biocatalysis and …, 2020 - Taylor & Francis
The enantiomeric metabolites D-xylulose-5-phosphate and L-xylulose-5-phosphate are
highly relevant in numerous important pathways from microbial to human metabolism. As …

L-fuculokinase-catalyzed phosphorylation and its use for the straightforward synthesis of L-fuculose-1-phosphate

N Hardt, S Kind, R Meier… - Biocatalysis and …, 2024 - Taylor & Francis
L-Fuculokinases play a key role in both natural and synthetic metabolic pathways, not only
for the utilization of L-fucose, but also for related monosaccharides, and catalyze selective …