Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Severe COVID‐19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals
PE Gray, AW Bartlett, SG Tangye - Clinical & Translational …, 2022 - Wiley Online Library
Since the emergence of the COVID‐19 pandemic in early 2020, a key challenge has been to
define risk factors, other than age and pre‐existing comorbidities, that predispose some …
define risk factors, other than age and pre‐existing comorbidities, that predispose some …
[HTML][HTML] Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID
NA Scott, L Pearmain, SB Knight… - European …, 2023 - Eur Respiratory Soc
Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …
[HTML][HTML] CXCL8, CCL2, and CMV seropositivity as new prognostic factors for a severe COVID-19 course
E Pius-Sadowska, A Niedźwiedź, P Kulig… - International journal of …, 2022 - mdpi.com
The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been
established that hyperinflammatory responses and cytokine storms play important roles. The …
established that hyperinflammatory responses and cytokine storms play important roles. The …
Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID‐19 outcomes: Genome‐wide …
Abstract Coronavirus Disease (COVID‐19) may cause a dysregulation of the immune
system and has complex relationships with multiple autoimmune diseases, including …
system and has complex relationships with multiple autoimmune diseases, including …
HLA‐dependent variation in SARS‐CoV‐2 CD8 + T cell cross‐reactivity with human coronaviruses
The conditions and extent of cross‐protective immunity between severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) …
syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) …
[HTML][HTML] rs71327024 Associated with COVID-19 Hospitalization Reduces CXCR6 Promoter Activity in Human CD4+ T Cells via Disruption of c-Myb Binding
Single-nucleotide polymorphism rs71327024 located in the human 3p21. 31 locus has been
associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21 …
associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21 …
ANANASTRA: annotation and enrichment analysis of allele-specific transcription factor binding at SNPs
A Boytsov, S Abramov, AZ Aiusheeva… - Nucleic Acids …, 2022 - academic.oup.com
Abstract We present ANANASTRA, https://ananastra. autosome. org, a web server for the
identification and annotation of regulatory single-nucleotide polymorphisms (SNPs) with …
identification and annotation of regulatory single-nucleotide polymorphisms (SNPs) with …
Role of different types of RNA molecules in the severity prediction of SARS-CoV-2 patients
P Jeyananthan - Pathology-Research and Practice, 2023 - Elsevier
SARS-CoV-2 pandemic is the current threat of the world with enormous number of
deceases. As most of the countries have constraints on resources, particularly for intensive …
deceases. As most of the countries have constraints on resources, particularly for intensive …
[HTML][HTML] Next-generation sequencing of host genetics risk factors associated with COVID-19 severity and long-COVID in Colombian population
M Angulo-Aguado, JC Carrillo-Martinez… - Scientific Reports, 2024 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) was considered a major public health
burden worldwide. Multiple studies have shown that susceptibility to severe infections and …
burden worldwide. Multiple studies have shown that susceptibility to severe infections and …