Synthetic biology efforts began in simple single-cell systems, which were relatively easy to
manipulate genetically (Cameron et al., 2014). The field grew exponentially in the last two …

Ubiquitous in embryonic development, tissue fusion is of interest to tissue engineers who
use tissue spheroids or organoids as building blocks of three-dimensional (3D) multicellular …

Motivation Due to the complexity and heterogeneity of multicellular biological systems,
mathematical models that take into account cell signalling, cell population behaviour and the …

Computational models of normal liver function and xenobiotic induced liver damage are
increasingly being used to interpret in vitro and in vivo data and as an approach to the de …

Mathematical modeling provides the predictive ability to understand the metabolic
reprogramming and complex pathways that mediate cancer cells' proliferation. We present a …

Cancer cells metabolize glucose through metabolic pathways that differ from those used by
healthy and differentiated cells. In particular, tumours have been shown to consume more …

It is widely agreed that keratinocyte migration plays a crucial role in wound re-
epithelialization. Defects in this function contribute to wound reoccurrence causing …

Virtually all arthropods all arthropods add their body segments sequentially, one by one in
an anterior to posterior progression. That process requires not only segment specification …

A major cause of cancer mortality is metastasis of cancer cells from a localized tumor to
other parts of the body. The interactions between cancer cells and the surrounding tumor …

Progress continues in the field of cancer biology, yet much remains to be unveiled regarding
the mechanisms of cancer invasion. In particular, complex biophysical mechanisms enable …