There is an ongoing shift in demographics such that older persons will outnumber young
persons in the coming years, and with it age-associated tissue attrition and increased …

Purpose Terrorist use of nuclear weapons and radiation accidents put the human population
at risk for exposure to life-threatening levels of radiation. Victims of lethal radiation exposure …

The hematopoietic system is highly sensitive to stress from both aging and radiation
exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be modeled in …

Lymphoid lineage recovery and involution after exposure to potentially lethal doses of
ionizing radiation have not been well defined, especially the long-term effects in aged …

Medical countermeasures (MCMs) for hematopoietic acute radiation syndrome (H-ARS)
should be evaluated in well-characterized animal models, with consideration of at-risk …

Abstract Purpose of Review Malicious or accidental radiation exposure increases risk for the
hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation …

Validation of biodosimetry assays is routinely performed using primarily orthovoltage
irradiators at a conventional dose rate of approximately 1 Gy/min. However …

Purpose To address confounding issues that have been noted in planning and conducting
studies to identify biomarkers of radiation injury, develop animal models to simulate these …

Animal models are necessary to demonstrate the efficacy of medical countermeasures
(MCM) to mitigate/treat acute radiation syndrome and the delayed effects of acute radiation …

The field of radiation countermeasures is growing, however, currently there are no effective
and non-toxic compounds which could be administered orally to the individuals post …