Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes are …

Following the decline of neurogenesis at birth, progenitors of the subventricular zone (SVZ)
remain mostly in a quiescent state in the adult human brain. The mechanisms that regulate …

The roles of Wnts in neural development, synaptogenesis, and cancer are generally well
characterized. Nonetheless, evidence exists that interactions between the immune and …

Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …

This study sought to determine whether deficient Igf1 expression in osteocytes would affect
loading-induced osteogenic response. Tibias of osteocyte Igf1 conditional knockout (KO) …

Tunneling nanotubes (TNT s) are actin‐based transient tubular connections that allow direct
communication between distant cells. TNT s play an important role in several physiological …

Purpose: ROR1, a receptor in the noncanonical Wnt/planar cell polarity (PCP) pathway, is
upregulated in malignant B cells of chronic lymphocytic leukemia (CLL) patients. It has been …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
progressive loss of dopaminergic (DA ergic) neuronal cell bodies in the substantia nigra …

Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the
maintenance of cellular homeostasis from the embryonic developmental stages to …