Pediatric central nervous system tumors are the most common solid malignancies in
childhood, and aggressive therapy often leads to long-term sequelae in survivors, making …

Mouse models of medulloblastoma have proven to be instrumental in understanding
disease mechanisms, particularly the role of epigenetic and molecular drivers, and …

Most current research on human brain tumors is focused on the molecular and cellular
analysis of the bulk tumor mass. However, there is overwhelming evidence in some …

In the mouse neocortex, neural progenitor cells generate both differentiating neurons and
daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein …

Purpose: Anti-programmed cell death protein 1 (PD-1) therapy has demonstrated
inconsistent therapeutic results in patients with glioblastoma (GBM) including those with …

Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown.
The recent identification of tumor-initiating cells in glioma, which share many similarities with …

Recent findings suggest that Notch signaling is active in brain tumors and stem cells, and
that stem cells or cells with progenitor characteristics contribute to brain tumor formation …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is
characterized by aggressive tumor behavior coupled with poor prognosis. Various etiologies …

Activation of sonic hedgehog (Shh) signaling occurs in the majority of pancreatic ductal
adenocarcinomas. Here we investigate the mechanisms by which Shh contributes to …

We examined the genetic requirements for the Myc family of oncogenes in normal Sonic
hedgehog (Shh)–mediated cerebellar granule neuronal precursor (GNP) expansion and in …