Eukaryotic cells display a wide range of morphologies important for cellular function and
development. A particular cell shape is made via the generation of asymmetry in the …

The cell wall (CW) is the outermost layer of fungi and other organisms. It exhibits a dynamic
structure and a characteristic chemical composition consisting almost entirely of interacting …

Linking bioactive compounds to their cellular targets is a central challenge in chemical
biology. Here we report the mode of action of theonellamides, bicyclic peptides derived from …

Schizosaccharomyces pombe contains four putative (1, 3) β-D-glucan synthase (GS)
catalytic subunits, Bgs1p-4p. In this work, we cloned bgs4+ and show that Bgs4p is the only …

Schizosaccharomyces pombe rho1+ and rho2+ genes are involved in the control of cell
morphogenesis, cell integrity, and polarization of the actin cytoskeleton. Although both …

The cell wall is a structure external to the plasma membrane that is essential for the survival
of the fungi. This polysaccharidic structure confers resistance to the cell internal turgor …

Schizosaccharomyces pombe cdc42+ regulates cell morphology and polarization of the
actin cytoskeleton. Scd1p/Ral1p is the only described guanine nucleotide exchange factor …

Cellular responses to external signals are regulated by conserved mitogen-activated protein
(MAP) kinase signaling cascades. These pathways are triggered by a vast range of stimuli …

The cell wall is a rigid structure essential for survival of the fungal cell. Because of its
absence in mammalian cells, the cell wall is an attractive target for antifungal agents. Thus …

In cell-walled organisms, a cross wall (septum) is produced during cytokinesis, which then
splits in certain organisms to allow the daughter cells to separate. The formation and the …