Super-resolution microscopy has overcome a long-held resolution barrier—the diffraction
limit—in light microscopy and enabled visualization of previously invisible molecular details …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

Actin and spectrin play important roles in neurons, but their organization in axons and
dendrites remains unclear. We used stochastic optical reconstruction microscopy to study …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

Traditionally, researchers have believed that axons are highly dependent on their cell
bodies for long-term survival. However, recent studies point to the existence of axon …

Due to their viscoelastic nature, white matter axons are susceptible to damage by high strain
rates produced during traumatic brain injury (TBI). Indeed, diffuse axonal injury (DAI) is one …

Little is known about which components of the axonal cytoskeleton might break during rapid
mechanical deformation, such as occurs in traumatic brain injury. Here, we micropatterned …

Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in
axons. How this membrane skeleton is developed and why it preferentially forms in axons …

Regeneration of injured neurons can restore function, but most neurons regenerate poorly
or not at all. The failure to regenerate in some cases is due to a lack of activation of cell …

Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton
(MPS) in neurons. In the MPS, short actin filaments, capped by actin-capping proteins, form …