Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
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The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …

Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

Meiosis in the female germ line of mammals is distinguished by a prolonged arrest in
prophase of meiosis I between homologous chromosome recombination and ovulation. How …

p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …

The tumor suppressor p53 is critically important in the cellular damage response and is the
founding member of a family of proteins. All three genes regulate cell cycle and apoptosis …

Notch signaling promotes commitment of keratinocytes to differentiation and suppresses
tumorigenesis. p63, a p53 family member, has been implicated in establishment of the …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

Heterozygous mutations in the transcription factor gene p63 are causative for several
syndromes, with ectodermal dysplasia, orofacial clefting and limb malformations as the key …

The survival rate of cancer patients is steadily increasing, owing to more efficient therapies.
Understanding the molecular mechanisms of chemotherapy-induced premature ovarian …