Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

The activation of dendritic cells, necessary for the initiation of primary and secondary
immune responses, can be induced by endogenous danger signals—released by tissues …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Nucleotides are emerging as an ubiquitous family of extracellular signaling molecules. It has
been known for many years that adenosine diphosphate is a potent platelet aggregating …

Abstract Background ATP-gated P2X7 is a non-selective cation channel, which participates
in a wide range of cellular functions as well as pathophysiological processes including …

Astrocyte glutamate release can modulate synaptic activity and participate in brain
intercellular signaling. P2X7receptors form large ion channels when activated by ATP or …

Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …

The P2X 7 receptor is a ligand-gated cation-selective channel that mediates ATP-induced
apoptosis of cells of the immune system. We and others have shown that P2X 7 is …