[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Roles and regulation of histone methylation in animal development
A Jambhekar, A Dhall, Y Shi - Nature reviews Molecular cell biology, 2019 - nature.com
Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …
arginine residues, and it can be governed by multiple positive and negative regulators, even …
[HTML][HTML] Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …
replication and can be inherited through mitosis. How this may sustain the epigenome and …
Nascent RNA analyses: tracking transcription and its regulation
The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …
genome. Decoding of this information begins with regulated transcription of genomic DNA …
[HTML][HTML] Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide
Polycomb group (PcG) proteins are required for normal differentiation and development and
are frequently deregulated in cancer. PcG proteins are involved in gene silencing; however …
are frequently deregulated in cancer. PcG proteins are involved in gene silencing; however …
Polycomb and Trithorax Group Genes in Drosophila
JA Kassis, JA Kennison, JW Tamkun - Genetics, 2017 - academic.oup.com
Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …
regulators of development and differentiation in metazoans. These two groups of genes …
Mechanisms of polycomb gene silencing: knowns and unknowns
JA Simon, RE Kingston - Nature reviews Molecular cell biology, 2009 - nature.com
Polycomb proteins form chromatin-modifying complexes that implement transcriptional
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …
silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins …
[HTML][HTML] KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …
[HTML][HTML] H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
H3K27 methylation mediated by the histone methyltransferase complex PRC2 is critical for
transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X …
transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X …
Trithorax group proteins: switching genes on and keeping them active
B Schuettengruber, AM Martinez, N Iovino… - … reviews Molecular cell …, 2011 - nature.com
Cellular memory is provided by two counteracting groups of chromatin proteins termed
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …
Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate …