[HTML][HTML] Breast cancer intrinsic subtype classification, clinical use and future trends
X Dai, T Li, Z Bai, Y Yang, X Liu, J Zhan… - American journal of …, 2015 - ncbi.nlm.nih.gov
Breast cancer is composed of multiple subtypes with distinct morphologies and clinical
implications. The advent of microarrays has led to a new paradigm in deciphering breast …
implications. The advent of microarrays has led to a new paradigm in deciphering breast …
Triple-negative breast cancer and the potential for targeted therapy
JR Jhan, ER Andrechek - Pharmacogenomics, 2017 - Taylor & Francis
Breast cancer is composed of several well-recognized subtypes including estrogen receptor,
progesterone receptor and HER2 triple-negative breast cancer (TNBC). Without available …
progesterone receptor and HER2 triple-negative breast cancer (TNBC). Without available …
A metastasis map of human cancer cell lines
Most deaths from cancer are explained by metastasis, and yet large-scale metastasis
research has been impractical owing to the complexity of in vivo models. Here we introduce …
research has been impractical owing to the complexity of in vivo models. Here we introduce …
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
Smoking has a profound impact on tumor immunity, and nicotine, which is the major
addictive component of smoke, is known to promote tumor progression despite being a non …
addictive component of smoke, is known to promote tumor progression despite being a non …
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Brain metastasis represents a substantial source of morbidity and mortality in various
cancers, and is characterized by high resistance to chemotherapy. Here we define the role …
cancers, and is characterized by high resistance to chemotherapy. Here we define the role …
Integrated molecular characterization of testicular germ cell tumors
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
Perturbation-response genes reveal signaling footprints in cancer gene expression
M Schubert, B Klinger, M Klünemann, A Sieber… - Nature …, 2018 - nature.com
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …
research. A common approach is to infer signaling activity of pathways from gene …
Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …
to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no …
Prognostic and predictive value of PDL1 expression in breast cancer
Expression of programmed cell death receptor ligand 1 (PDL1) has been scarcely studied in
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
Molecular subgroups of medulloblastoma: the current consensus
Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …