Transcription factors recognize and bind to consensus sequence elements that are specific
for each transcription factor, and the transcription factors then regulate downstream gene …

Acute myeloid leukemia (AML) is a complex disease characterized by a diverse range of
recurrent molecular aberrations that occur in many different combinations. Components of …

Abstract Changes in gene regulation and expression govern orderly transitions from
hematopoietic stem cells to terminally differentiated blood cell types. These transitions are …

Analysis of circulating tumor DNA (ctDNA) can be used to characterize and monitor cancers.
Recently, non-invasive prenatal testing (NIPT) as a new next-generation sequencing (NGS) …

Background Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs)(eg
gefitinib) currently remain the first-line treatment for patients with advanced non-small-cell …

Background Hashimoto's thyroiditis (HT) is a chronic autoimmune disease that poses a risk
factor for papillary thyroid carcinoma (PTC). The present study aimed to identify the key …

Arsenic, a class I human carcinogen, is ubiquitously found throughout the environment and
around the globe, posing a great public health concern. Notably, Bangladesh and regions of …

Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of
Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role …

Simple Summary In tumorigenesis, aberrant DNA methylation may be an earlier and
stronger modifier of gene expression than mutations. Herein, 128 serous ovarian tumors …

Aberrant expression of certain glycosphingolipids (GSLs) is associated with the
differentiation of acute myeloid leukemia (AML) cells. However, the expression patterns of …