Simple Summary Scrapie is a naturally occurring transmissible spongiform encephalopathy
of sheep and goats. Polymorphisms in single nucleotides in the coding sequence of the …

Goats are adapted to live in harsh areas of the world ensuring minimum levels of milk and
meat production without much economic input. Scrapie is a fatal prion disease of small …

Introduction Paratuberculosis (PTB) is a worldwide chronic, contagious enteric disease
caused by Mycobacterium avium subsp. paratuberculosis (MAP) mainly affecting ruminant …

Polymorphisms at PRNP gene locus have been associated with resistance against classical
scrapie in goats. Genetic selection on this gene within appropriate breeding programs may …

Background Classical scrapie susceptibility in sheep has been linked to three
polymorphisms at codon 136, 154, and 171 in the prion protein gene (PRNP) whereas …

Scrapie is a fatal, neurodegenerative disease that affects sheep and goat worldwide,
belonging to the group of transmissible spongiform encephalopathies (TSEs). Since 2002 …

Background Polymorphisms of the prion protein gene may influence scrapie susceptibility in
small ruminants through modified protein conformation. At least 47 amino acid substitutions …

Background: The variability of prion protein gene (PRNP) codons and the frequency of
alleles (K222, D146, and S146) that appear to confer genetic resistance to classical scrapie …

Prion diseases in livestock can be a potential danger for humans as well. The Makuei sheep
breed is one of the most important sources of protein in Iran. In this study, the polymorphism …

Scrapie resistance or susceptibility in sheep is associated with single nucleotide
polymorphisms (SNPs) at codons 136, 154, and 171 of the prion protein gene (PRNP). In …