This systematic review sets out to give a comprehensive overview of the cytokine profile at
the onset of psychosis un-confounded by medication. We aim to provide insight into the …

A pressing need for interrater reliability in the diagnosis of mental disorders emerged during
the mid-twentieth century, prompted in part by the development of diverse new treatments …

We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

There is increasing evidence that genome-wide association (GWA) studies represent a
powerful approach to the identification of genes involved in common human diseases. We …

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937
controls) and tested loci with P< 10− 5 in up to 16,726 additional subjects. Of 12 loci …

The use of networks to integrate different genetic, proteomic, and metabolic datasets has
been proposed as a viable path toward elucidating the origins of specific diseases. Here we …

Gene–environment interplay is a general term that covers several divergent concepts with
different meanings and different implications. In this review, we evaluate research evidence …

Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have
traditionally focused on genetic and environmental risk factors, although more recent work …

There is substantial evidence for partial overlap of genetic influences on schizophrenia and
bipolar disorder, with family, twin, and adoption studies showing a genetic correlation …