Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

Although radiotherapy is an essential modality in the treatment of colorectal cancer (CRC),
the incidence of radioresistance remains high clinically. Long noncoding RNAs (lncRNAs) …

Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/
autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for …

Background: Tumor cells require proficient autophagy to meet high metabolic demands and
resist chemotherapy, which suggests that reducing autophagic flux might be an attractive …

We postulated that expression differences of autophagy-related genes are instrumental in
stratifying the risk of early relapse after surgery and evaluating the prognosis of patients with …

Autophagy plays a key role in eliminating and recycling cellular components in response to
stress, including starvation. Dysregulation of autophagy is observed in various diseases …

Background Human osteosarcoma is the most common primary cancer of the bone. Multiple
mechanisms underlying cell growth, apoptosis, bone development, and drug resistance are …

Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the
lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 …

Advanced gastric cancer (GCa) remains highly lethal due to the lack of effective therapies.
Identifying promising therapeutic targets and developing effective treatment against GCa are …