ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

The appearance of modular proteins is a widespread phenomenon during the evolution of
proteins. The combinatorial arrangement of different functional and/or structural domains …

Apicomplexan parasites have challenged researchers for nearly a century. A major
challenge to developing efficient treatments and vaccines is the parasite's ability to change …

Malaria remains a heavy public health and socioeconomic burden in tropical and
subtropical regions. Increasing resistance against front-line treatments implies that novel …

The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological
processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a …

Abstract Calcium-Dependent Protein Kinase 5 (CDPK5) protein is one of the family
members of a calcium-dependent protein kinase that is found in plants and some species of …

Calcium ions are used as important signals during various physiological processes. In
malaria parasites, Plasmodium spp., calcium dependent protein kinases (CDPKs) have …

Malaria etiologies with pathophysiological similarities to hypertension currently constitute a
major subject of research. The malaria-high blood pressure hypothesis is strongly supported …

Calcium-dependent protein kinases (CDPKs) are considered promising targets for
pharmaceutical intervention of cryptosporidiosis. Whole-genome sequencing has revealed …

Malaria continues to impinge heavily on mankind, with five continents still under its clasp.
Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current …