Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) …

A Beckers, LA Aaltonen, AF Daly, A Karhu - Endocrine reviews, 2013 - academic.oup.com
Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

AHR-mediated immunomodulation: the role of altered gene transcription

NI Kerkvliet - Biochemical pharmacology, 2009 - Elsevier
The immune system is a sensitive target for aryl hydrocarbon receptor (AHR)-mediated
transcriptional regulation. Most of the cells that participate in immune responses express …

[HTML][HTML] AhR sensing of bacterial pigments regulates antibacterial defence

P Moura-Alves, K Faé, E Houthuys, A Dorhoi… - Nature, 2014 - nature.com
The aryl hydrocarbon receptor (AhR) is a highly conserved ligand-dependent transcription
factor that senses environmental toxins and endogenous ligands, thereby inducing …

Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD)

HY Kim, TH Yoo, Y Hwang, GH Lee, B Kim, J Jang… - Scientific reports, 2017 - nature.com
Progressive renal failure causes uremia-related immune dysfunction, which features a
chronic inflammatory milieu. Given the central role of end-stage renal disease (ESRD) …

Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways

T Haarmann-Stemmann, H Bothe, J Abel - Biochemical pharmacology, 2009 - Elsevier
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant,
which causes a variety of severe health effects, eg immunosuppression, hepatotoxicity, and …

TCDD toxicity mediated by epigenetic mechanisms

B Patrizi, M Siciliani de Cumis - International journal of molecular …, 2018 - mdpi.com
Dioxins are highly toxic and persistent halogenated organic pollutants belonging to two
families ie, Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Polychlorinated Dibenzo …

Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance

J Lindén, S Lensu, J Tuomisto, R Pohjanvirta - Frontiers in …, 2010 - Elsevier
Dioxins are ubiquitous environmental contaminants that have attracted toxicological interest
not only for the potential risk they pose to human health but also because of their unique …

Indoxyl sulfate–induced TNF‐α is regulated by crosstalk between the aryl hydrocarbon receptor, NF‐κB, and SOCS2 in human macrophages

HY Kim, TH Yoo, JY Cho, HC Kim… - The FASEB …, 2019 - Wiley Online Library
Indoxyl sulfate (IS) is a uremic toxin associated with increased prevalence of cardiovascular
diseases (CVDs) in patients with chronic kidney disease. Despite the crucial role of uremia …

Lung cancer associated with combustion particles and fine particulate matter (PM2. 5)-The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon …

JA Holme, J Vondráček, M Machala… - Biochemical …, 2023 - Elsevier
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …

Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production

T Chiba, H Uchi, G Tsuji, H Gondo, Y Moroi… - Pulmonary pharmacology …, 2011 - Elsevier
The dioxins and dioxin-like compounds in cigarette smoke regulate various immunological
responses via the arylhydrocarbon receptor (AhR). These environmental toxicants are …